Preparationa and Characterization of domperidone Inclusion complexes with cyclodextrin: Influence of preparation method

Domperidone is a widely used antiemetic, poorly water soluble drug, erratically absorbed in stomach and possess several dissolution-related problems thus it has poor bioavailability. Solubility of a drug plays a very important role in dissolution and hence absorption of drug which ultimately affects its bioavailability. Hence, by considering the facts related to drug, attempts have been made to formulate inclusion complexes using methylated ?-cyclodextrin and also to study the effect of preparation method. Inclusion complexes were prepared using methylated ?-cyclodextrin in 1:1 and 1:2 molar ratios. Kneading, ultrasonification and physical mixture method were used for preparation of inclusion complexes. All the inclusion complexes were characterized using FTIR, DSC and XRD. The solubility and dissolution results revealed that there was a considerable increase in solubility and dissolution of all inclusion complexes as compared to pure drug. It was highest in case of methylated ?-cyclodextrin in 1:1 molar ratio using ultrasonification method (USM1). Stability study revealed that all complexes were stable for a period of three months.